Drug General Information
Drug ID
DXX3J7
Drug Name
2-tert-Butyloxycarbonylamino-6,7-methylenedioxy-1-(4-methoxyphenyl)-2H-isoquinolin-3-one
Synonyms
CHEMBL594179
Indication Discovery agent Investigative [1587926]
Formula
C22H22N2O6
Canonical SMILES
COc1ccc(cc1)C2=C3C=C4OCOC4=CC3=CC(=O)N2NC(=O)OC(C)(C)C
InChI
InChI=1S/C22H22N2O6/c1-22(2,3)30-21(26)23-24-19(25)10-14-9-17-18(29-12-28-17)11-16(14)20(24)13-5-7-15(27-4)8-6-13/h5-11H,12H2,1-4H3,(H,23,26)
InChIKey
GLQYBHSWTNIFJZ-UHFFFAOYSA-N
Target and Pathway
Target(s) Cathepsin L Target Info [1587926]
Cathepsin B Target Info [1587926]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritishsa04142:Lysosome
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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