Drug General Information
Drug ID
DXY0AF
Drug Name
5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1,2,3,4-tetrahydroquinolin-3-ol
Synonyms
CHEMBL1644761
Indication Discovery agent Investigative [1587926]
Formula
C22H25ClN2O
Canonical SMILES
Cc1cc(c(Cl)c2c1NC(C)(C)C(O)C2(C)C)c3cccc4cc[nH]c34
InChI
InChI=1S/C22H25ClN2O/c1-12-11-15(14-8-6-7-13-9-10-24-19(13)14)17(23)16-18(12)25-22(4,5)20(26)21(16,2)3/h6-11,20,24-26H,1-5H3
InChIKey
VWTXAIVZMCQYKU-UHFFFAOYSA-N
Target and Pathway
Target(s) Progesterone receptor Target Info [1587926]
mRNA of androgen receptor Target Info [1587926]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturationhsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Cellular roles of Anthrax toxinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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