Drug General Information
Drug ID
DXZ1OK
Drug Name
[3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(quinolin-5-yloxy)-ethyl]-amine
Synonyms
CHEMBL126536
Indication Discovery agent Investigative [1587926]
Formula
C22H22FN3O
Canonical SMILES
Fc1ccc2[nH]cc(CCCNCCOc3cccc4ncccc34)c2c1
InChI
InChI=1S/C22H22FN3O/c23-17-8-9-21-19(14-17)16(15-26-21)4-2-10-24-12-13-27-22-7-1-6-20-18(22)5-3-11-25-20/h1,3,5-9,11,14-15,24,26H,2,4,10,12-13H2
InChIKey
FKQLIZKVHZDRRD-UHFFFAOYSA-N
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info [1587926]
Sodium-dependent serotonin transporter Target Info [1587926]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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