Drug General Information
Drug ID
DXZ1UX
Drug Name
3-Bromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]benzenesulfonamide
Synonyms
CHEMBL1672432
Indication Discovery agent Investigative [1587926]
Formula
C12H14BrN3O2S
Canonical SMILES
C[C@H]1C[C@H](CN1C#N)NS(=O)(=O)c2cccc(Br)c2
InChI
InChI=1S/C12H14BrN3O2S/c1-9-5-11(7-16(9)8-14)15-19(17,18)12-4-2-3-10(13)6-12/h2-4,6,9,11,15H,5,7H2,1H3/t9-,11+/m0/s1
InChIKey
ORFRHRXPOJVPSF-GXSJLCMTSA-N
Target and Pathway
Target(s) Cathepsin K Target Info [1587926]
Cathepsin L Target Info [1587926]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritishsa04142:Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast SignalingWP2572:Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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