Drug General Information
Drug ID
DXZR0H
Drug Name
(Z)-N-[3-({3-[3-(Diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)-2-oxoindolin-5-yl]benzenesulfonamide
Synonyms
CHEMBL1215347
Indication Discovery agent Investigative [1587926]
Formula
C30H34N4O4S
Canonical SMILES
CCN(CC)CCCc1c(\\C=C\\2/C(=O)Nc3ccc(NS(=O)(=O)c4ccccc4)cc23)[nH]c5CCCC(=O)c15
InChI
InChI=1S/C30H34N4O4S/c1-3-34(4-2)17-9-12-22-27(31-26-13-8-14-28(35)29(22)26)19-24-23-18-20(15-16-25(23)32-30(24)36)33-39(37,38)21-10-6-5-7-11-21/h5-7,10-11,15-16,18-19,31,33H,3-4,8-9,12-14,17H2,1-2H3,(H,32,36)/b24-19-
InChIKey
BZDPNSHFCIPOPU-CLCOLTQESA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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