Drug Information

Drug General Information
Drug ID
D00AWT
Former ID
DAP000413
Drug Name
Propericiazine
Synonyms
Aolept; Nemactil; Neulactil; Neuleptil; PERICYAZINE; Periciazina; Periciazine; Periciazinum; Piperocyanomazine;Periciazine [INN]; Bayer 1409; IC 6002; RP 8908; WH 7508; Neulactil (TN); Neuleptil (TN); Periciazina [INN-Spanish]; Periciazinum [INN-Latin]; Propericiazine (JAN); Propericiazine(jan); SKF 20,716; Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine; Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine [French]; 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile; 10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile; 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile; 2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine; 2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine; 6909 RP
Drug Type
Small molecular drug
Indication Psychiatric disorder [ICD9: 290-319; ICD10:F01-F99] Approved [533807], [537783], [551439]
Therapeutic Class
Antipsychotic Agents
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL
Formula
C21H23N3OS
Canonical SMILES
C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
InChI
1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
InChIKey
LUALIOATIOESLM-UHFFFAOYSA-N
CAS Number
CAS 2622-26-6
PubChem Compound ID
4747
PubChem Substance ID
7703132, 7848548, 7980281, 8150082, 8152913, 10516133, 11336049, 11361288, 11364508, 11367070, 11369632, 11371656, 11373958, 11377794, 11462260, 11485343, 11489420, 11490564, 11492025, 11495428, 14803709, 26612557, 26680430, 26748871, 26748872, 29223833, 46505085, 47291188, 47810806, 48259291, 50006266, 50107474, 56464150, 57322425, 79997266, 85789600, 92124822, 99301962, 103555929, 103846500, 104307313, 117515052, 124636904, 126673224, 128541428, 131349353, 134224641, 134337709, 134982092, 136913034
ChEBI ID
ChEBI:31981
SuperDrug ATC ID
N05AC01
SuperDrug CAS ID
cas=002622266
Target and Pathway
Target(s) Alpha-1B adrenergic receptor Target Info Binder [537783]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 533807Affinity of neuroleptics for D1 receptor of human brain striatum. J Psychiatry Neurosci. 1994 Jul;19(4):265-9.
Ref 537783Interaction of neuroleptics and antidepressants with rat brain alpha 2-receptors: a possible relationship between alpha 2-receptor antagonism and antidepressant action. Biol Psychiatry. 1984 Sep;19(9):1283-91.
Ref 551439Drug Information of Troleandomycin from nextbio research in illumina. 2015.
Ref 537783Interaction of neuroleptics and antidepressants with rat brain alpha 2-receptors: a possible relationship between alpha 2-receptor antagonism and antidepressant action. Biol Psychiatry. 1984 Sep;19(9):1283-91.

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