Drug Information

Drug General Information
Drug ID
D00BWZ
Former ID
DNC011044
Drug Name
N-(pyridin-3-yl)indoline-1-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551219]
Structure
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2D MOL

3D MOL
Formula
C14H13N3O
Canonical SMILES
C1CN(C2=CC=CC=C21)C(=O)NC3=CN=CC=C3
InChI
1S/C14H13N3O/c18-14(16-12-5-3-8-15-10-12)17-9-7-11-4-1-2-6-13(11)17/h1-6,8,10H,7,9H2,(H,16,18)
InChIKey
ODXHNGJYIWHPAG-UHFFFAOYSA-N
PubChem Compound ID
10823903
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Inhibitor [551219]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 551219Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. doi: 10.1016/j.bmc.2010.05.017. Epub 2010 May 15.
Ref 551219Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. doi: 10.1016/j.bmc.2010.05.017. Epub 2010 May 15.

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