Drug Information

Drug General Information
Drug ID
D00CDM
Former ID
DIB020653
Drug Name
PD 128907
Synonyms
PD128907; PD-128,907
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543321]
Structure
Download
2D MOL
Formula
C14H19NO3
InChI
InChI=1S/C14H19NO3/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15/h3-4,8,12,14,16H,2,5-7,9H2,1H3/t12-,14-/m0/s1
InChIKey
YOILXOMTHPUMRG-JSGCOSHPSA-N
PubChem Compound ID
115107
PubChem Substance ID
29296657, 47288997, 50070451, 50071095, 53084510, 57309683, 57338995, 103312146, 103989292, 104253493, 104397601, 126671699, 135072927, 135650793, 144240143, 178100335, 184526621, 223656747, 223705246, 235957792, 252216003
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [534074]
D(3) dopamine receptor Target Info Agonist [534074]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 543321(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 952).
Ref 534074Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J Pharmacol Exp Ther. 1995 Dec;275(3):1355-66.

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