Drug General Information
Drug ID	D00DPJ
Former ID	DIB007546
Drug Name	Amezinium
Synonyms	Amezinium methyl sulfate
Drug Type	Small molecular drug
Indication	Hypotension [ICD9: 458, 796.3; ICD10:I95]		Approved	[551871]
Structure		Download 2D MOL 3D MOL
Formula	C12H15N3O5S
Canonical SMILES	COc1cc(N)cn[n+]1c2ccccc2
InChI	1S/C11H11N3O/c1-15-11-7-9(12)8-13-14(11)10-5-3-2-4-6-10/h2-8,12H,1H3/p+1
InChIKey	VXROHTDSRBRJLN-UHFFFAOYSA-O
PubChem Compound ID	56973695
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Modulator	[533574], [551871]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 533574	Pharmacology of amezinium, a novel antihypotensive drug. III. Studies on the mechanism of action. Arzneimittelforschung. 1981;31(9a):1558-65.
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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