Drug Information

Drug General Information
Drug ID
D00DPP
Former ID
DIB009369
Drug Name
CYCLOPLATAM
Synonyms
Ammine(cyclopentanamine)[(S)-hydroxybutanedioato(2-)-O1,O4]platinum; (S)-(-)-Malatoammine(cyclopentylamine)platinum (II)
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 2 [526263]
Structure
Download
2D MOL

3D MOL
Formula
C9H18N2O5Pt
Canonical SMILES
C1CCC(C1)N.C(C(C(=O)[O-])O)C(=O)[O-].N.[Pt+2]
InChI
1S/C5H11N.C4H6O5.H3N.Pt/c6-5-3-1-2-4-5;5-2(4(8)9)1-3(6)7;;/h5H,1-4,6H2;2,5H,1H2,(H,6,7)(H,8,9);1H3;/q;;;+2/p-2
InChIKey
OPWOOOGFNULJAQ-UHFFFAOYSA-L
PubChem Compound ID
3035239
PubChem Substance ID
10048302, 15007196, 36078764, 50018493, 57353064, 80894550, 111638487, 127319956, 127319957, 127319958, 127319959, 127319960, 127319961, 127319962, 127319963, 135074185
Target and Pathway
Target(s) Protein kinase C Target Info Inhibitor [534310]
References
Ref 526263Results of phase II clinical trial of cycloplatam in refractory solid tumors. Vopr Onkol. 2001;47(6):752-6.
Ref 534310Effect of anti-tumor agents cisplatin and cycloplatam on membrane protein kinase C activity in murine T-lymphocytes. Biokhimiia. 1996 Oct;61(10):1866-73.

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