Drug Information

Drug General Information
Drug ID
D00FGV
Former ID
DAP001069
Drug Name
Carbinoxamine
Synonyms
Allergefon; Carbinoxamina; Carbinoxaminum; Clistin; Clistine; Paracarbinoxamine; Paracarinoxamine; Rotoxamine; Carbinoxamine base; Carbinoxamina [INN-Spanish]; Carbinoxamine (INN); Carbinoxamine [INN:BAN]; Carbinoxaminum [INN-Latin]; Clistin (TN); McN-R 73Z; Palgic (TN); {2-[(4-Chlorophenyl)-2-pyridylmethoxy]ethyl}dimethylamine; N,N-Dimethyl-2-(p-chloro-alpha-(2-pyridyl)benzyloxy)ethylamine; Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-N,N-dimethyl-(9CI); (+-)-Carbinoxamine; 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine; 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine; 2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine; 2-{[(4-chlorophenyl)(pyridin-2-yl)methyl]oxy}-N,N-dimethylethanamine
Drug Type
Small molecular drug
Indication Seasonal and perennial allergic rhinitis and vasomotor rhinitis [ICD10:J30] Approved [551871]
Therapeutic Class
Antihistamines
Company
McNeil Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C16H19ClN2O
InChI
InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3
InChIKey
OJFSXZCBGQGRNV-UHFFFAOYSA-N
CAS Number
CAS 486-16-8
PubChem Compound ID
2564
PubChem Substance ID
9088, 615221, 5051969, 7978860, 8151694, 10523882, 10527104, 11335994, 11361233, 11362934, 11365496, 11368058, 11371253, 11373867, 11376220, 11462205, 11466829, 11467949, 11484729, 11486318, 11488943, 11490143, 11492079, 11493914, 16888880, 29217899, 29221724, 46506787, 47515357, 47736528, 47885455, 48110489, 48110490, 48110491, 48185036, 48259277, 48415697, 49698846, 50032039, 50111737, 50111738, 51091926, 77851965, 85209627, 85788414, 87245633, 92721277, 92729945, 103224683, 104300953
SuperDrug ATC ID
R06AA08
SuperDrug CAS ID
cas=000486168
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [537829]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537829Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain. Naunyn Schmiedebergs Arch Pharmacol. 1994 Feb;349(2):140-4.

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