Drug Information

Drug General Information
Drug ID
D00HDU
Former ID
DAP000586
Drug Name
Moexipril
Synonyms
Moexiprilum; Uniretic; Moexipril (INN); Moexipril [INN:BAN]; Moexiprilum [INN-Latin]; Perdix (TN); Univasc (TN); (3S)-2-(N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl)-6,7-bis(methyloxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [536361], [541695]
Therapeutic Class
Antihypertensive Agents
Company
Ucb Inc
Structure
Download
2D MOL

3D MOL
Formula
C27H34N2O7
InChI
InChI=1S/C27H34N2O7/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32)/t17-,21-,22-/m0/s1
InChIKey
UWWDHYUMIORJTA-HSQYWUDLSA-N
CAS Number
CAS 103775-10-6
PubChem Compound ID
91270
PubChem Substance ID
9906, 7980014, 10224695, 14884255, 14933223, 44422239, 46508441, 48416289, 50077632, 51009191, 85789110, 93166165, 96024913, 103339306, 103831006, 103984203, 104404350, 117576966, 126683035, 129432080, 134222210, 134337877, 135049415, 135153605, 137003828, 141323944, 143493279, 151982736, 152164600, 152238590, 160964036, 162178212, 164786738, 172914179, 175266162, 178103185, 179149500, 184545955, 223440353, 223653409, 224369399, 226420555, 252390154
SuperDrug ATC ID
C09AA13
SuperDrug CAS ID
cas=103775106
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [537123]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541695(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6571).
Ref 537123Moexipril for Treatment of Primary Biliary Cirrhosis in Patients with an Incomplete Response to Ursodeoxycholic Acid. Dig Dis Sci. 2009 Mar 3.

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