Drug Information

Drug General Information
Drug ID
D00HPK
Former ID
DAP000752
Drug Name
Naftifine
Synonyms
Naftifin; Naftifina; Naftifinum; Naftifine HCl; Naftifina [INN-Spanish]; Naftifine (INN); Naftifine [INN:BAN]; Naftifinum[INN-Latin]; Naftin (TN); SN 105-843; N-cinnamyl-N-methyl-1-naphthalenemethylamine hydrochloride; N-Methyl-N-(1-naphthyl methyl)-3-phenyl-2-propen-1-amine(E), hydrochloride; (2E)-N-methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine; (E)-N-Cinnamyl-N-methyl-1-naphthalenemethylamine; (E)-N-Cinnamyl-N-methyl-1-naphthalinmethylamin; (E)-N-Cinnamyl-N-methyl-1-naphthylmethylamin; (E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine
Drug Type
Small molecular drug
Indication Dermatomycosis [ICD10:B36.0] Approved [538523], [551871]
Therapeutic Class
Antifungal Agents
Company
Merz Pharmaceuticals Llc
Structure
Download
2D MOL

3D MOL
Formula
C21H21N
Canonical SMILES
CN(CC=CC1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32
InChI
1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+
InChIKey
OZGNYLLQHRPOBR-DHZHZOJOSA-N
CAS Number
CAS 65472-88-0
PubChem Compound ID
47641
PubChem Substance ID
10271, 603411, 7980063, 8180321, 14942609, 34712608, 47646744, 47720796, 48094744, 48169595, 49699388, 50065026, 50124043, 50962514, 85788086, 96024933, 103188450, 103840051, 104057027, 104353418, 117392353, 124766151, 126533983, 126629054, 126657705, 126685418, 134338038, 135029113, 137006423, 142192259, 144106432, 175266913, 177749226, 179150867, 179225939, 184546230, 196106120, 223440381, 223677934, 224441276, 226432968, 229686166, 251912313, 251916624, 252354411, 252817647
SuperDrug ATC ID
D01AE22
SuperDrug CAS ID
cas=065472880
Target and Pathway
Target(s) Squalene monooxygenase Target Info Inhibitor [537454], [537992]
KEGG Pathway Steroid biosynthesis
Sesquiterpenoid and triterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
References
Ref 538523FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019356.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537454Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1193-9.
Ref 537992Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob Agents Chemother. 1996 Feb;40(2):443-7.

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