TTD | Drug: D00HWF

Drug General Information
Drug ID	D00HWF
Former ID	DNC002359
Drug Name	Proxyfan
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538770]
Structure		Download 2D MOL 3D MOL
Formula	C13H16N2O
InChI	InChI=1S/C13H16N2O/c1-2-5-12(6-3-1)10-16-8-4-7-13-9-14-11-15-13/h1-3,5-6,9,11H,4,7-8,10H2,(H,14,15)
InChIKey	WNWALBVQAAIULR-UHFFFAOYSA-N
PubChem Compound ID	6421522
PubChem Substance ID	15018514, 29215555, 43015674, 49846729, 50425566, 56224795, 85083153, 85789097, 103184079, 103995299, 114519688, 135279529, 135650860, 136065000, 137132887, 140691979, 144233393, 230033402, 240855570, 249954442
Target and Pathway
Target(s)	Histamine H3 receptor	Target Info	Antagonist	[536039]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
Reactome	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538770	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1255).
Ref 536039	The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.

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Drug Information