Drug Information

Drug General Information
Drug ID
D00JSG
Former ID
DIB010689
Drug Name
Fluoratec
Synonyms
Technepine; DAT imaging agent, Alseres; DAT imaging agent, Boston life Sciences; DAT imaging agent, Harvard University; Dopamine transporter imaging agent, Alseres; Dopamine transporter imaging agent, Boston life Sciences; O-1505; O-1505T; O-1506; O-1730; O-1783; O-1794; O-861T; Dopamine transporter imaging agent, Harvard/MIT/Organix; 99mTc-O-1505; 99mTc-O-1505T
Indication Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] Terminated [547430]
Company
Harvard University
Structure
Download
2D MOL

3D MOL
Canonical SMILES
N(CC(=O)[N-]CC[S-])(CC[S-])CCCN1[C@H]2[C@H]([C@@H](C[C@<br/>@H]1CC2)c1ccc(cc1)F)C(=O)CC.[99Tc+3]=O
Target and Pathway
Target(s) Sodium-dependent dopamine transporter Target Info Modulator [534375]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 547430Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016245)
Ref 534375Technepine: a high-affinity 99m-technetium probe to label the dopamine transporter in brain by SPECT imaging. Synapse. 1996 Mar;22(3):239-46.

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