Drug General Information
Drug ID	D00KVE
Former ID	DIB000567
Drug Name	Cutamesine
Synonyms	AGY-94806; Msc-1; SA-4502; SA-4503; Sigma opioid receptor agonist, Santen
Drug Type	Small molecular drug
Indication	Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32]		Preclinical	[546327]
Company	Santen Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C23H32N2O2
Canonical SMILES	N1(CCc2cc(c(cc2)OC)OC)CCN(CC1)CCCc1ccccc1
PubChem Compound ID	9907323
Target and Pathway
Target(s)	Sigma(1)-type opioid receptor	Target Info	Agonist	[526642], [532713], [534601]
WikiPathways	miR-targeted genes in squamous cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
References
Ref 546327	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007486)
Ref 526642	Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6.
Ref 532713	Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
Ref 534601	Effect of SA4503, a novel sigma1 receptor agonist, against glutamate neurotoxicity in cultured rat retinal neurons. Eur J Pharmacol. 1998 Jan 19;342(1):105-11.

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