Drug Information

Drug General Information
Drug ID
D00LBX
Former ID
DNC000319
Drug Name
Bicuculline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539464]
Structure
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2D MOL

3D MOL
Formula
C20H17NO6
InChI
InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChIKey
IYGYMKDQCDOMRE-ZWKOTPCHSA-N
CAS Number
CAS 485-49-4
PubChem Compound ID
10237
PubChem Substance ID
11555, 90838, 3151977, 7978788, 8138145, 8149737, 8157382, 10321197, 11335784, 11361023, 11461995, 11466617, 11467737, 11486393, 15953321, 24848584, 29228758, 47736466, 47810739, 47810740, 47959732, 48035105, 48184980, 48259218, 48259219, 48334478, 49698571, 49746882, 49971723, 50557195, 53789175, 56311924, 56463577, 57326063, 61282576, 85305365, 88771100, 92125404, 92303463, 99301697, 103177562, 103913677, 103915241, 104322745, 118046944, 118055390, 121363075, 124559143, 124559289, 124749560
SuperDrug ATC ID
A02BC05
SuperDrug CAS ID
cas=161973100
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor Target Info Antagonist [534920]
Glutamate receptor AMPA subtype Target Info Antagonist [535600]
References
Ref 539464(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2312).
Ref 534920GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala. J Neurosci. 1999 Nov 15;19(22):9698-704.
Ref 535600Effects of subcutaneous administration of the gamma-aminobutyric acid(A) receptor agonist muscimol on water intake in water-deprived rats. Physiol Behav. 2002 Nov;77(2-3):445-50.

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