Drug Information

Drug General Information
Drug ID
D00MYQ
Former ID
DAP000863
Drug Name
Protriptyline
Synonyms
Amimetilina; Impril; Maximed; Novopramine; Protriptilina; Protriptylinum; Protryptyline; Rhotrimine; Triptil; Triptyl; Vivactil; Vivactyl; Triptil hydrochloride; Normethyl EX4442; Triadapin 5; Apo-Imipramine; Apo-Trimip; Novo-Doxepin; Novo-Tripramine; Protriptilina [INN-Spanish]; Protriptyline (INN); Protriptyline [INN:BAN]; Protriptylinum [INN-Latin]; Vivactil (TN); N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine; N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine; N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine; N-3-(5H-Dibenzo(a,d)cyclohepten-5-yl)propyl-N-methylamine; 3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine; 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine; 5-(3-Methylaminopropyl)-5H-Dibenzo[a,d]cycloheptene; 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene; 5H-Dibenzo[a, d]cycloheptene-5-propanamine, N-methyl-, hydrochloride; 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene
Drug Type
Small molecular drug
Indication Depression; Bipolar disorder [ICD9: 311, 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300; ICD10:F30-F39, F31, F40-F42] Approved [536306], [542305], [551871]
Therapeutic Class
Antidepressants
Company
Teva Womens Health Inc
Structure
Download
2D MOL

3D MOL
Formula
C19H21N
InChI
InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3
InChIKey
BWPIARFWQZKAIA-UHFFFAOYSA-N
CAS Number
CAS 438-60-8
PubChem Compound ID
4976
PubChem Substance ID
9612, 794681, 4903494, 7849630, 7980423, 8153064, 10522905, 11111679, 11111680, 11466958, 11468078, 11486755, 15221639, 29214865, 29224052, 46505128, 47291296, 47365392, 47589161, 47736675, 47736676, 47959952, 48035323, 48416494, 49699033, 49961823, 50100330, 50104299, 57322553, 78122381, 85177328, 85209617, 85787376, 90341254, 92714631, 93167175, 96025133, 103189728, 104061736, 104307929, 124750138, 124881218, 124881219, 124881220, 126623989, 127578602, 134338142, 134974679, 137001421, 142365103
ChEBI ID
ChEBI:8597
SuperDrug ATC ID
N06AA11
SuperDrug CAS ID
cas=000438608
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [537742]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 536306Emerging treatments for depression. Expert Opin Pharmacother. 2006 Dec;7(17):2323-39.
Ref 542305(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7285).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537742Analgesic properties of intrathecally administered heterocyclic antidepressants. Pain. 1987 Mar;28(3):343-55.

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