Drug Information

Drug General Information
Drug ID
D00NPT
Former ID
DNC000949
Drug Name
Minodronate
Drug Type
Small molecular drug
Indication Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890] Approved [546292], [551871]
Structure
Download
2D MOL

3D MOL
Formula
C9H12N2O7P2
Canonical SMILES
C1=CC2=NC=C(N2C=C1)CC(O)(P(=O)(O)O)P(=O)(O)O
InChI
1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18)
InChIKey
VMMKGHQPQIEGSQ-UHFFFAOYSA-N
PubChem Compound ID
130956
PubChem Substance ID
7843852, 10242764, 12014461, 14874799, 29196193, 29196330, 29309444, 48426327, 53837734, 56374449, 57343615, 75971565, 87457604, 93309669, 99375738, 103314069, 104374011, 124894544, 125823092, 126651847, 126666053, 129496050, 131302852, 135268217, 135649663, 137084388, 141698785, 144206806, 151995601, 160650211, 160655146, 162205070, 162222716, 163416705, 164777754, 164779842, 164779843, 171578885, 175438067, 179322955, 184547763, 186024269, 196109800, 198979870, 206246374, 223589663, 223662192, 224339905, 226511683, 249828272
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [535102]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 546292Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007280)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535102Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42.

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