Drug Information

Drug General Information
Drug ID
D00PEU
Former ID
DIB020731
Drug Name
pirenperone
Synonyms
R-47465
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539871]
Structure
Download
2D MOL
Formula
C23H24FN3O2
InChI
InChI=1S/C23H24FN3O2/c1-16-20(23(29)27-12-3-2-4-21(27)25-16)11-15-26-13-9-18(10-14-26)22(28)17-5-7-19(24)8-6-17/h2-8,12,18H,9-11,13-15H2,1H3
InChIKey
HXCNRYXBZNHDNE-UHFFFAOYSA-N
PubChem Compound ID
4847
PubChem Substance ID
855539, 5518524, 8152980, 10321799, 11111590, 11111591, 11341934, 11362117, 11364478, 11367040, 11369602, 11372728, 11374319, 11377764, 11466559, 11467679, 11485635, 11486198, 11487519, 11489496, 11491470, 11492435, 11495398, 14756637, 17405565, 24278110, 26612664, 26680560, 26746907, 26746908, 29223928, 46386967, 47207164, 47291338, 47440496, 47810995, 47959985, 48110691, 48185200, 48259470, 49698543, 50065155, 50100304, 50103904, 50103905, 50122680, 50122681, 52893072, 53778113, 56422490
Target and Pathway
Target(s) 5-hydroxytryptamine 7 receptor Target Info Antagonist [534463]
KEGG Pathway Ras signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539871(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 283).
Ref 534463Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). Br J Pharmacol. 1997 Sep;122(1):126-32.

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