Drug Information

Drug General Information
Drug ID
D00PXO
Former ID
DIB018909
Drug Name
CGK733
Synonyms
CGK733
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541214]
Structure
Download
2D MOL
Formula
C23H18Cl3FN4O3S
InChI
InChI=1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35)
InChIKey
HLCDNLNLQNYZTK-UHFFFAOYSA-N
PubChem Compound ID
6605258
PubChem Substance ID
11114625, 11164639, 22391633, 24640128, 24724454, 26758161, 29203588, 29217536, 43224989, 50111704, 50554646, 53800986, 57371156, 85083168, 85787673, 98629307, 99302614, 104242356, 114638881, 117645996, 125503183, 134964067, 135348704, 135698776, 162023471, 162124860, 162250092, 163620943, 163686265, 163688667, 164045287, 172913233, 175607451, 178102552, 179694519, 184813120, 208265192, 208265505, 223377718, 223404308, 228140564, 241376046, 242060234, 245597933, 251971091, 252156674, 252215124, 252300148, 252441266, 252451362
Target and Pathway
Target(s) Serine threonine protein kinase ATR Target Info Inhibitor [528249]
ATM serine/threonine kinase Target Info Inhibitor [528249]
KEGG Pathway Fanconi anemia pathway
Cell cycle
p53 signaling pathway
HTLV-I infection
PANTHER Pathway p53 pathway
p53 pathway feedback loops 2
Pathway Interaction Database Fanconi anemia pathway
ATR signaling pathway
Signaling events mediated by TCPTP
Circadian rhythm pathway
BARD1 signaling events
p53 pathway
Reactome Meiotic synapsis
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
G2/M DNA damage checkpoint
WikiPathways DNA Damage Response
Meiotic Synapsis
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell Cycle
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage Response
References
Ref 541214(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5929).
Ref 528249Small molecule-based reversible reprogramming of cellular lifespan. Nat Chem Biol. 2006 Jul;2(7):369-74. Epub 2006 Jun 11.

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