Drug Information

Drug General Information
Drug ID
D00QOF
Former ID
DIB000806
Drug Name
ORG-13011
Synonyms
1-[4-[4-[4-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]butyl]pyrrolidin-2-one fumarate
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Phase 2 [521409]
Structure
Download
2D MOL

3D MOL
Formula
C19H29N5O2
Canonical SMILES
CC1(C)CC(=O)N(CCCCN2CCN(CC2)c3ncccn3)C(=O)C1
InChI
1S/C19H29N5O2/c1-19(2)14-16(25)24(17(26)15-19)9-4-3-8-22-10-12-23(13-11-22)18-20-6-5-7-21-18/h5-7H,3-4,8-15H2,1-2H3
InChIKey
QOIGKGMMAGJZNZ-UHFFFAOYSA-N
PubChem Compound ID
55191
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [525547], [551871]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 521409ClinicalTrials.gov (NCT00000189) Gepirone vs Placebo in Treatment of Cocaine Dependence - 3. U.S. National Institutes of Health.
Ref 525547Antagonism of the 5-HT1A receptor stimulus in a conditioned taste aversion procedure. Eur Neuropsychopharmacol. 1999 Jun;9(4):345-9.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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