Drug Information

Drug General Information
Drug ID
D00QXV
Former ID
DIB007732
Drug Name
BMS-181101
Synonyms
1H-Indole
Drug Type
Small molecular drug
Indication Mood disorder [ICD10:F30-F39] Discontinued in Phase 2 [538662], [545877]
Company
Bristol-Myers Squibb Co
Structure
Download
2D MOL

3D MOL
Formula
C20H24FN5O
InChI
InChI=1S/C20H24FN5O/c1-27-19-13-22-14-24-20(19)26-9-7-25(8-10-26)6-2-3-15-12-23-18-5-4-16(21)11-17(15)18/h4-5,11-14,23H,2-3,6-10H2,1H3
InChIKey
NRLXAYBZNVHRFL-UHFFFAOYSA-N
PubChem Compound ID
177836
PubChem Substance ID
14803935, 23920935, 33501191, 53787437, 78813413, 85210052, 104426709, 135650000, 135873853, 137998010, 142709069, 230293678
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Antagonist [525577], [551730]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538662(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 108).
Ref 545877Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005177)
Ref 525577Sensitive triple-quadrupole mass spectrometric assay for the determination of BMS-181885, a 5-HT1 agonist, in human plasma following solid phase extraction. Biomed Chromatogr. 1999 Oct;13(6):425-30.
Ref 551730Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.

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