Drug Information

Drug General Information
Drug ID
D00RDE
Former ID
DNC010203
Drug Name
4-(4'-N-Methylphenyl)diazenylbenzenesulfonamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530399]
Structure
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2D MOL

3D MOL
Formula
C13H14N4O2S
Canonical SMILES
CNC1=CC=C(C=C1)N=NC2=CC=C(C=C2)S(=O)(=O)N
InChI
1S/C13H14N4O2S/c1-15-10-2-4-11(5-3-10)16-17-12-6-8-13(9-7-12)20(14,18)19/h2-9,15H,1H3,(H2,14,18,19)
InChIKey
RMLHDMTUTOMVIX-UHFFFAOYSA-N
PubChem Compound ID
44246261
Target and Pathway
Target(s) Carbonic anhydrase XII Target Info Inhibitor [530399]
Carbonic anhydrase IX Target Info Inhibitor [530399]
KEGG Pathway Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP2877:Vitamin D Receptor Pathway
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
References
Ref 530399Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. Epub 2009 Sep 6.Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XIIover the cytosolic isoforms I and II.
Ref 530399Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. Epub 2009 Sep 6.Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XIIover the cytosolic isoforms I and II.

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