Drug Information

Drug General Information
Drug ID
D00SEB
Former ID
DAP000585
Drug Name
Enalapril
Synonyms
Vasotec; Enalapril (INN); Enalapril (TN); Renitec (TN); Vasotec (TN); N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl-L-proline; N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline; (2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [536095], [541468]
Therapeutic Class
Antihypertensive Agents
Company
Merck & Co
Structure
Download
2D MOL

3D MOL
Formula
C20H28N2O5
InChI
InChI=1S/C20H28N2O5/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25)/t14-,16-,17-/m0/s1
InChIKey
GBXSMTUPTTWBMN-XIRDDKMYSA-N
CAS Number
CAS 75847-73-3
PubChem Compound ID
5388962
PubChem Substance ID
9191, 7979157, 11112847, 11335583, 11360822, 11364201, 11366763, 11369325, 11372634, 11373494, 11377487, 11461794, 11485085, 11489271, 11491293, 11491823, 11495121, 14779899, 14877707, 17185069, 29214998, 39404326, 46507920, 47365119, 47588933, 47588934, 47810682, 48110391, 48184936, 48415941, 49698433, 50073899, 50103938, 50103939, 53787340, 57362754, 75931775, 89736144, 92309084, 93166909, 96024588, 99313640, 103179319, 103928457, 113955320, 127931871, 134358398, 135012773, 137100856, 140098266
SuperDrug ATC ID
C09AA02
SuperDrug CAS ID
cas=075847733
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [537534]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 536095New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22.
Ref 541468(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6322).
Ref 537534Determination of bezafibrate, methotrexate, cyclophosphamide, orlistat and enalapril in waste and surface waters using on-line solid-phase extraction liquid chromatography coupled to polarity-switching electrospray tandem mass spectrometry. J Environ Monit. 2009 Apr;11(4):830-8. Epub 2009 Jan 21.

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