Drug Information

Drug General Information
Drug ID
D00SVP
Former ID
DIB006508
Drug Name
PF-4455242
Synonyms
PF-04455242
Drug Type
Small molecular drug
Indication Bipolar disorder [ICD9: 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300; ICD10:F31, F40-F42] Phase 1 [522809]
Company
Pfizer Inc
Structure
Download
2D MOL

3D MOL
Formula
C21H29ClN2O2S
Canonical SMILES
CC(C)CNCc1ccc(cc1)c2ccccc2S(=O)(=O)N3CCCC3
InChI
1S/C21H28N2O2S/c1-17(2)15-22-16-18-9-11-19(12-10-18)20-7-3-4-8-21(20)26(24,25)23-13-5-6-14-23/h3-4,7-12,17,22H,5-6,13-16H2,1-2H3
InChIKey
OWVIKBRKPCTDEP-UHFFFAOYSA-N
PubChem Compound ID
53465410
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Modulator [531552]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 522809ClinicalTrials.gov (NCT00988949) Proof Of Mechanism Study To Determine Efficacy Of PF-04455242 In Blocking Spiradoline (PF-00345768) Stimulated Prolactin Release. U.S. National Institutes of Health.
Ref 531552Design and discovery of a selective small molecule ? opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242). J Med Chem. 2011 Aug 25;54(16):5868-77.

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