TTD | Drug: D00TUB

Drug General Information
Drug ID	D00TUB
Former ID	DNC011635
Drug Name	2-(4-Amino-phenyl)-8-hydroxy-3H-quinazolin-4-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534774]
Structure		Download 2D MOL 3D MOL
Formula	C14H11N3O2
Canonical SMILES	C1=CC2=C(C(=C1)O)NC(=NC2=O)C3=CC=C(C=C3)N
InChI	1S/C14H11N3O2/c15-9-6-4-8(5-7-9)13-16-12-10(14(19)17-13)2-1-3-11(12)18/h1-7,18H,15H2,(H,16,17,19)
InChIKey	FNYTYXJFOSRUTI-UHFFFAOYSA-N
PubChem Compound ID	10491078
Target and Pathway
Target(s)	Poly [ADP-ribose] polymerase-1	Target Info	Inhibitor	[534774]
KEGG Pathway	Base excision repair
KEGG Pathway	NF-kappa B signaling pathway
PANTHER Pathway	FAS signaling pathway
Pathway Interaction Database	Integrin-linked kinase signaling
	Caspase Cascade in Apoptosis
	Notch-mediated HES/HEY network
Reactome	Dual Incision in GG-NER
WikiPathways	FAS pathway and Stress induction of HSP regulation
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Nanoparticle triggered regulated necrosis
	Corticotropin-releasing hormone
References
Ref 534774	J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Ref 534774	J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

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Drug Information