Drug Information

Drug General Information
Drug ID
D00UEQ
Former ID
DNC000630
Drug Name
Etomoxir
Drug Type
Small molecular drug
Indication Heart failure [ICD9: 428; ICD10:I50] Terminated [533432]
Structure
Download
2D MOL

3D MOL
Formula
C17H23ClO4
Canonical SMILES
CCOC(=O)C1(CO1)CCCCCCOC2=CC=C(C=C2)Cl
InChI
1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3
InChIKey
DZLOHEOHWICNIL-UHFFFAOYSA-N
CAS Number
CAS 124083-20-1
PubChem Compound ID
123823
PubChem Substance ID
6070434, 10240872, 14777309, 26719759, 29304010, 46386895, 49681665, 50002002, 53642310, 87692428, 92308531, 103824883, 104419407, 117577956, 124658837, 124953656, 124958351, 126435320, 127809295, 135078811, 138845576, 141768074, 162022285, 162262944, 162726096, 172080203, 179295904, 179322899, 226975899, 241163461, 252349776
Target and Pathway
Target(s) Carnitine O-palmitoyltransferase I Target Info Modulator [533432]
KEGG Pathway Fatty acid degradation
Fatty acid metabolism
PPAR signaling pathway
AMPK signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
PathWhiz Pathway Fatty acid Metabolism
Reactome RORA activates gene expression
PPARA activates gene expression
Import of palmitoyl-CoA into the mitochondrial matrix
WikiPathways SIDS Susceptibility Pathways
Mitochondrial LC-Fatty Acid Beta-Oxidation
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
Fatty Acid Beta Oxidation
AMPK Signaling
References
Ref 533432Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine. Circ Res. 1988 Dec;63(6):1036-43.
Ref 533432Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine. Circ Res. 1988 Dec;63(6):1036-43.

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