Drug General Information
Drug ID
D00VAN
Former ID
DNC010337
Drug Name
[(3-Bromophenyl)-m-tolyl-ketone]thiosemicarbazone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530644]
Structure
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2D MOL

3D MOL

Formula
C15H14BrN3S
Canonical SMILES
CC1=CC=CC(=C1)C(=NNC(=S)N)C2=CC(=CC=C2)Br
InChI
1S/C15H14BrN3S/c1-10-4-2-5-11(8-10)14(18-19-15(17)20)12-6-3-7-13(16)9-12/h2-9H,1H3,(H3,17,19,20)/b18-14+
InChIKey
UUHYYCURIRMTND-NBVRZTHBSA-N
PubChem Compound ID
Target and Pathway
Target(s) Cathepsin L Target Info Inhibitor [530644]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 530644Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. Epub 2010 Jan 6.Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors.
Ref 530644Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. Epub 2010 Jan 6.Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors.

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