Drug General Information
Drug ID	D00VKV
Former ID	DNC003501
Drug Name	Tenocyclidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551400]
Structure		Download 2D MOL 3D MOL
Formula	C15H23NS
Canonical SMILES	C1CCC(CC1)(C2=CC=CS2)N3CCCCC3
InChI	1S/C15H23NS/c1-3-9-15(10-4-1,14-8-7-13-17-14)16-11-5-2-6-12-16/h7-8,13H,1-6,9-12H2
InChIKey	JUZZEWSCNBCFRL-UHFFFAOYSA-N
CAS Number	CAS 21500-98-1
PubChem Compound ID	62751
PubChem Substance ID	5276595, 8188273, 14798602, 29216149, 43119828, 46505124, 50017186, 57314831, 77137543, 103188676, 103904012, 103917857, 104326548, 109613831, 117404002, 128331477, 134222130, 135019317, 137001269, 144205386, 160644985, 160964767, 179323264, 198948198, 226830037, 241039513, 249964299
Target and Pathway
Target(s)	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Antagonist	[551400]
	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Antagonist	[551400]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Dopaminergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Huntington's disease
	Systemic lupus erythematosus
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
	Reelin signaling pathway
Reactome	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascade
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
	BDNF signaling pathway
References
Ref 551400	The binding of [3H]thienyl cyclohexylpiperidine ([3H]<span class="caps">TCP</span>) to the <span class="caps">NMDA</span>-phencyclidine receptor complex. Neuropharmacology. 1989 Jan;28(1):1-7.
Ref 551400	The binding of [3H]thienyl cyclohexylpiperidine ([3H]<span class="caps">TCP</span>) to the <span class="caps">NMDA</span>-phencyclidine receptor complex. Neuropharmacology. 1989 Jan;28(1):1-7.

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