Drug Information

Drug General Information
Drug ID
D00VNH
Former ID
DNC014630
Drug Name
ZK-200775
Drug Type
Small molecular drug
Indication Coronary artery disease [ICD9: 410-414, 429.2; ICD10:I20-I25] Phase 1 [527708], [542619]
Structure
Download
2D MOL

3D MOL
Formula
C14H15F3N3O6P
InChI
InChI=1S/C14H15F3N3O6P/c15-14(16,17)8-5-9-11(6-10(8)19-1-3-26-4-2-19)20(7-27(23,24)25)13(22)12(21)18-9/h5-6H,1-4,7H2,(H,18,21)(H2,23,24,25)
InChIKey
WZMQMKNCWDCCMT-UHFFFAOYSA-N
PubChem Compound ID
208953
PubChem Substance ID
9368758, 14806271, 29215531, 30413591, 50067808, 52020190, 57399573, 85756762, 85786999, 103086264, 103150048, 103184959, 113442193, 117626692, 134351835, 135183466, 135698626, 135745722, 140862569, 141003653, 144205298, 162023352, 162799219, 163782383, 170466123, 179322906, 196680101, 198967209, 223365971, 226392887, 226687302, 241375895, 249617549, 252156459, 252481672
Target and Pathway
Target(s) Glutamate receptor AMPA subtype Target Info Inhibitor [526053]
References
Ref 527708The AMPA antagonist ZK 200775 in patients with acute ischaemic stroke: a double-blind, multicentre, placebo-controlled safety and tolerability study. Cerebrovasc Dis. 2005;20(5):304-9. Epub 2005 Aug30.
Ref 542619(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7636).
Ref 526053Bioorg Med Chem Lett. 2001 May 7;11(9):1205-10.Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.