Drug General Information
Drug ID	D00VSQ
Former ID	DIB015228
Drug Name	E-1455
Synonyms	E-1043; Clozapine prodrug (oral, ECLYPS), ProCor Pharmaceuticals
Indication	Schizophrenia [ICD9: 295; ICD10:F20]		Investigative	[543567]
Company	ProCor Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Canonical SMILES	O=P(OC)(N1CCN(C2=Nc3c(Nc4c2cccc4)ccc(c3)Cl)CC1)OC
CAS Number	CAS 5786-21-0
Target and Pathway
Target(s)	D(4) dopamine receptor	Target Info	Modulator	[543567]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Dopaminergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, Other
References
Ref 543567	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 217).
Ref 543567	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 217).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.