Drug General Information
Drug ID
D00VXM
Former ID
DIB019782
Drug Name
droxinostat
Synonyms
NS-41080; NS41080
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530619]
Structure
Download
2D MOL
Formula
C11H14ClNO3
InChI
InChI=1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14)
InChIKey
JHSXDAWGLCZYSM-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Histone deacetylase-3 Target Info Inhibitor [530619]
Histone Deacetylase 8 Target Info Inhibitor [530619]
Histone deacetylase 6 Target Info Inhibitor [530619]
KEGG Pathway Thyroid hormone signaling pathway
Alcoholism
Viral carcinogenesishsa05034:Alcoholism
Viral carcinogenesis
PANTHER Pathway Wnt signaling pathwayP00057:Wnt signaling pathway
Pathway Interaction Database Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class I
Retinoic acid receptors-mediated signaling
Validated targets of C-MYC transcriptional repression
Regulation of retinoblastoma proteinhdac_classi_pathway:Signaling events mediated by HDAC Class Ihdac_classii_pathway:Signaling events mediated by HDAC Class II
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histonesR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
Assembly of the primary cilium
WikiPathways Integrated Pancreatic Cancer Pathway
Neural Crest Differentiation
Cell CycleWP2858:Ectoderm Differentiation
Cell Cycle
References
Ref 530619Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56.
Ref 530619Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56.

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