Drug General Information
Drug ID	D00WEQ
Former ID	DNC011760
Drug Name	Brolamfetamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539004]
Structure		Download 2D MOL 3D MOL
Formula	C11H16BrNO2
InChI	InChI=1S/C11H16BrNO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3
InChIKey	FXMWUTGUCAKGQL-UHFFFAOYSA-N
PubChem Compound ID	62065
PubChem Substance ID	3249526, 7516923, 8187862, 10518483, 10531667, 15071198, 43119241, 46507989, 47359939, 47805577, 50064682, 50113080, 50566377, 57314585, 85208881, 103164704, 103918766, 104324859, 117388967, 124893454, 127913862, 134223389, 134348965, 135028812, 135057191, 135650198, 135651149, 137005383, 160964741, 164840081, 179293614, 227004198, 241061107, 249912203, 252330132
Target and Pathway
Target(s)	5-hydroxytryptamine 1D receptor	Target Info	Inhibitor	[533498]
	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[529463]
	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[533498]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04020:Calcium signaling pathway
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR downstream signaling
	GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 539004	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 163).
Ref 529463	Bioorg Med Chem. 2008 Jun 1;16(11):6242-51. Epub 2008 May 6.'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines.
Ref 533498	J Med Chem. 1986 Feb;29(2):194-9.5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues.

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