Drug General Information
Drug ID	D00XWB
Former ID	DIB001382
Drug Name	F-15845
Drug Type	Small molecular drug
Indication	Angina pectoris [ICD9: 413; ICD10:I20]		Phase 1	[548229]
Company	Pierre Fabre SA
Structure		Download 2D MOL 3D MOL
Formula	C20H26BrNO2S2
CAS Number	CAS 470454-73-0
PubChem Compound ID	72941926
Target and Pathway
Target(s)	Sodium channel protein type 5 subunit alpha	Target Info	Inhibitor	[531108], [532635]
KEGG Pathway	Adrenergic signaling in cardiomyocytes
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Interaction between L1 and Ankyrins
WikiPathways	SIDS Susceptibility Pathways
	Cardiac Progenitor Differentiation
References
Ref 548229	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023448)
Ref 531108	Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias. Br J Pharmacol. 2010 Sep;161(1):79-91.
Ref 532635	A rare loss-of-function SCN5A variant is associated with lidocaine-induced ventricular fibrillation. Pharmacogenomics J. 2014 Aug;14(4):372-5.

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