Drug Information

Drug General Information
Drug ID
D00XWD
Former ID
DAP001526
Drug Name
Tegaserod
Synonyms
Tegaserod (USAN/INN); 1-[[(Z)-(5-methoxyindol-3-ylidene)methyl]amino]-2-pentylguanidine
Drug Type
Small molecular drug
Indication Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1] Approved [551871]
Dyspepsia; Gastro-oesophageal reflux; Irritable bowel syndrome [ICD9: 536.8, 530, 564.1, 787.91; ICD10:K30, K21, A09, K58, K59.1] Withdrawn from market [536224], [539432]
Company
Novartis
Structure
Download
2D MOL

3D MOL
Formula
C16H23N5O
InChI
InChI=1S/C16H23N5O/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15/h6-7,9-11,20H,3-5,8H2,1-2H3,(H3,17,18,21)/b12-11+
InChIKey
JWXDRFUZDKKGDV-VAWYXSNFSA-N
CAS Number
CAS 189188-57-6
PubChem Compound ID
5362436
PubChem Substance ID
11364906, 11367468, 11370030, 11372869, 11374139, 11378200, 11484916, 11488916, 11491670, 11492545, 11495764, 14776170, 14776171, 26612950, 26749090, 26749091, 34746101, 39384500, 46523984, 47207714, 47662545, 47960011, 48110734, 50107521, 50107522, 53788768, 56464350, 57362102, 78780358, 92124752, 92712636, 93301629, 103276928, 104098381, 114150049, 116933602, 126625387, 126656585, 126667358, 134338707, 134358317, 135018998, 135087697, 135374357, 135651238, 137090514, 137175472, 138069543, 138069544, 138069548
ChEBI ID
ChEBI:51044
SuperDrug ATC ID
A06AX06
SuperDrug CAS ID
cas=145158710
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Agonist [536224]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 536224Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
Ref 539432(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 226).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536224Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.

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