Drug Information

Drug General Information
Drug ID
D00YSJ
Former ID
DCL000313
Drug Name
Tecadenoson
Synonyms
CVT-510; Tecadenoson (USAN/INN); N-(3-Tetrahydrofuranyl)-6-aminopurine riboside; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diol
Drug Type
Small molecular drug
Indication Atrial fibrillation; Cardiac arrhythmias [ICD9: 272, 427.31, 427; ICD10:E78, I48, I47-I49] Discontinued in Phase 3 [540960], [546828]
Company
CV Therapeutics
Structure
Download
2D MOL

3D MOL
Formula
C14H19N5O5
InChI
InChI=1S/C14H19N5O5/c20-3-8-10(21)11(22)14(24-8)19-6-17-9-12(15-5-16-13(9)19)18-7-1-2-23-4-7/h5-8,10-11,14,20-22H,1-4H2,(H,15,16,18)/t7-,8-,10-,11-,14-/m1/s1
InChIKey
OESBDSFYJMDRJY-BAYCTPFLSA-N
CAS Number
CAS 204512-90-3
PubChem Compound ID
158795
PubChem Substance ID
10253429, 12015133, 14900100, 14924656, 46234173, 47207677, 50074092, 51311408, 57348546, 103540106, 104096341, 113440833, 128798234, 134338969, 134340519, 135114581, 137263966, 140172360, 175426918, 178102227, 179150149, 198937424, 223837114, 226596561, 241050748
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Agonist [535721], [551534]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540960(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5592).
Ref 546828Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010504)
Ref 535721Adenosine receptors and cardiovascular disease: the adenosine-1 receptor (A1) and A1 selective ligands. Cardiovasc Toxicol. 2003;3(1):71-88.
Ref 551534CV Therapeutics. Company report from CV Therapeutics, Inc. CV Therapeutics. 2009.

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