TTD | Drug: D00ZGF

Drug General Information
Drug ID	D00ZGF
Former ID	DIB016259
Drug Name	DA-6886
Synonyms	5-HT4 agonist (IBS-c), Dong-A
Indication	Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1]		Phase 1	[523965]
Company	Dong-A Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	5-hydroxytryptamine 4 receptor	Target Info	Agonist	[543971]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	5HT4 type receptor mediated signaling pathway
PathWhiz Pathway	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome	Serotonin receptors
Reactome	G alpha (s) signalling events
WikiPathways	Serotonin Receptor 4/6/7 and NR3C Signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 523965	ClinicalTrials.gov (NCT01633723) Phase I Clinical Trial of DA-6886 in Healthy Male Subjects. U.S. National Institutes of Health.
Ref 543971	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 9).

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Drug Information