Drug Information

Drug General Information
Drug ID
D01APL
Former ID
DIB020292
Drug Name
lysergol
Synonyms
lysergole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538742]
Structure
Download
2D MOL
Formula
C16H18N2O
InChI
InChI=1S/C16H18N2O/c1-18-8-10(9-19)5-13-12-3-2-4-14-16(12)11(7-17-14)6-15(13)18/h2-5,7,10,15,17,19H,6,8-9H2,1H3/t10-,15-/m1/s1
InChIKey
BIXJFIJYBLJTMK-MEBBXXQBSA-N
PubChem Compound ID
14987
PubChem Substance ID
7837025, 7979835, 8149859, 8161237, 10321383, 11113286, 11335690, 11360929, 11461901, 11466482, 11467602, 11486203, 15114793, 24824134, 29282975, 47216743, 47291095, 47440211, 47662242, 47810715, 47810716, 48035071, 48259195, 48334452, 49698503, 57328820, 75296128, 81093511, 85789344, 85789392, 88783025, 92125494, 99301603, 103158497, 103214383, 103913880, 103927877, 104335888, 117613576, 118048600, 121363165, 124813263, 127522274, 127583727, 134978869, 135650564, 135837847, 137119908, 139428243, 162189587
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Agonist [527380]
5-hydroxytryptamine 1B receptor Target Info Agonist [534239]
5-hydroxytryptamine 1E receptor Target Info Agonist [534239]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 538742(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 123).
Ref 527380Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4.
Ref 534239Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. J Neurochem. 1996 Nov;67(5):2096-103.

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