Drug General Information
Drug ID
D01ARG
Former ID
DIB000372
Drug Name
DB-900
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Investigative [550862]
Company
DARA BioSciences
Target and Pathway
Target(s) Peroxisome proliferator activated receptor alpha Target Info Agonist [550862]
Peroxisomeproliferator activated receptor delta Target Info Agonist [550862]
Peroxisome proliferator activated receptor gamma Target Info Agonist [550862]
KEGG Pathway PPAR signaling pathway
cAMP signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis Chsa03320:PPAR signaling pathway
Wnt signaling pathway
Pathways in cancer
Acute myeloid leukemiahsa03320:PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
Transcriptional misregulation in cancer
Thyroid cancer
NetPath Pathway IL2 Signaling PathwayNetPath_13:IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Wnt signaling pathwayP06959:CCKR signaling map ST
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorps1pathway:Presenilin action in Notch and Wnt signaling
RXR and RAR heterodimerization with other nuclear receptorwnt_noncanonical_pathway:Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
RXR and RAR heterodimerization with other nuclear receptor
Regulation of retinoblastoma protein
Reactome RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian ClockR-HSA-200425:Import of palmitoyl-CoA into the mitochondrial matrix
Regulation of pyruvate dehydrogenase (PDH) complex
Nuclear Receptor transcription pathwayR-HSA-1989781:PPARA activates gene expression
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
PPAR Alpha Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Activation of Gene Expression by SREBP (SREBF)
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Circadian Clock
Nuclear ReceptorsWP399:Wnt Signaling Pathway and Pluripotency
NRF2 pathway
Vitamin D Receptor Pathway
Ectoderm Differentiation
Nuclear ReceptorsWP363:Wnt Signaling Pathway Netpath
Differentiation of white and brown adipocyte
SREBP signalling
Nuclear Receptors
References
Ref 550862CN patent application no. 102459215, 3-(4-aminophenyl)-2-furancarboxylic acid derivative and pharmaceutically acceptable salt thereof.
Ref 550862CN patent application no. 102459215, 3-(4-aminophenyl)-2-furancarboxylic acid derivative and pharmaceutically acceptable salt thereof.

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