Drug General Information
Drug ID	D01BPF
Former ID	DIB016206
Drug Name	Avitriptan
Synonyms	Avitriptan fumarate; BMS-180048
Drug Type	Small molecular drug
Indication	Migraine [ICD9: 346; ICD10:G43]		Discontinued in Phase 3	[545344]
Company	Bristol-Myers Squibb Co
Structure		Download 2D MOL 3D MOL
Formula	C22H30N6O3S
Canonical SMILES	S(=O)(=O)(Cc1cc2c(c[nH]c2cc1)CCCN1CCN(c2c(OC)cncn2)CC1)<br />NC
PubChem Compound ID	133081
Target and Pathway
Target(s)	5-hydroxytryptamine 1D receptor	Target Info	Agonist	[534756], [551730]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545344	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002927)
Ref 534756	Safety trial with the 5HT1B/1D agonist avitriptan (BMS-180048) in patients with migraine who have experienced pressure, tightness, and/or pain in the chest, neck, and/or throat following sumatriptan.Cephalalgia. 1998 Oct;18(8):546-51.
Ref 551730	Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.