Drug Information

Drug General Information
Drug ID
D01BUS
Former ID
DIB012344
Drug Name
CA9-ADC
Synonyms
MN-IC; CA IX inhibitor (solid tumor, ADC, HuCAL), MorphoSys/Bayer Schering Pharma; Carbonic anhydrase IX inhibitor (solid tumor, antibody-drug conjugate, HuCAL), MorphoSys/Bayer Schering Pharma
Drug Type
Antibody
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 1 [549015]
Company
MorphoSys AG
Target and Pathway
Target(s) Carbonic anhydrase IX Target Info [531730]
KEGG Pathway Nitrogen metabolism
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxide
WikiPathways Vitamin D Receptor Pathway
Reversible Hydration of Carbon Dioxide
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
References
Ref 549015Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031507)
Ref 531730Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9. Mol Cancer Ther. 2012 Feb;11(2):340-9.

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