Drug General Information
Drug ID
D01CDL
Former ID
DNC003560
Drug Name
L-652731
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526814]
Structure
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2D MOL

3D MOL

Formula
C22H28O7
Canonical SMILES
COC1=CC(=C(C=C1C2CCC(O2)C3=CC(=C(C=C3OC)OC)OC)OC)OC
InChI
1S/C22H28O7/c1-23-17-11-21(27-5)19(25-3)9-13(17)15-7-8-16(29-15)14-10-20(26-4)22(28-6)12-18(14)24-2/h9-12,15-16H,7-8H2,1-6H3/t15-,16-/m1/s1
InChIKey
BNAYTLLYBCCIOF-HZPDHXFCSA-N
PubChem Compound ID
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Inhibitor [526814]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 526814J Med Chem. 1992 Sep 18;35(19):3474-82.Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester.
Ref 526814J Med Chem. 1992 Sep 18;35(19):3474-82.Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester.

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