Drug Information

Drug General Information
Drug ID
D01DIQ
Former ID
DNC010485
Drug Name
Alstiphyllanine F
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530756]
Structure
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2D MOL

3D MOL
Formula
C32H36N2O9
Canonical SMILES
CC=C1CN2C3CC1C(C45C3(NC6=C4C=C(C=C6)OC)OC2C5)(COC(=O)C7<br />=CC(=C(C(=C7)OC)OC)OC)C(=O)OC
InChI
1S/C32H36N2O9/c1-7-17-15-34-25-13-20(17)30(29(36)41-6,16-42-28(35)18-10-23(38-3)27(40-5)24(11-18)39-4)31-14-26(34)43-32(25,31)33-22-9-8-19(37-2)12-21(22)31/h7-12,20,25-26,33H,13-16H2,1-6H3/b17-7-/t20-,25-,26-,30-,31-,32-/m0/s1
InChIKey
JIBNKPQBEIZZCU-DYWXBFQLSA-N
PubChem Compound ID
46229072
Target and Pathway
Target(s) Sodium/glucose cotransporter 1 Target Info Inhibitor [530756]
mRNA of sodium-glucosetransporter-2 Target Info Inhibitor [530756]
KEGG Pathway Carbohydrate digestion and absorption
Bile secretion
Mineral absorption
PathWhiz Pathway Lactose Degradation
Trehalose Degradation
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transportersR-HSA-189200:Hexose transport
Inositol transporters
WikiPathways NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Metabolism of carbohydratesWP2884:NRF2 pathway
References
Ref 530756Bioorg Med Chem. 2010 Mar 15;18(6):2152-8. Epub 2010 Feb 6.Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.
Ref 530756Bioorg Med Chem. 2010 Mar 15;18(6):2152-8. Epub 2010 Feb 6.Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.

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