Drug Information

Drug General Information
Drug ID
D01FFX
Former ID
DNC009134
Drug Name
4-((naphthalen-2-yloxy)methyl)piperidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530012]
Structure
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2D MOL

3D MOL
Formula
C16H19NO
Canonical SMILES
C1CNCCC1COC2=CC3=CC=CC=C3C=C2
InChI
1S/C16H19NO/c1-2-4-15-11-16(6-5-14(15)3-1)18-12-13-7-9-17-10-8-13/h1-6,11,13,17H,7-10,12H2
InChIKey
MUOXAGUZMVATIC-UHFFFAOYSA-N
PubChem Compound ID
24691160
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [530012]
Sodium-dependent serotonin transporter Target Info Inhibitor [530012]
5-hydroxytryptamine receptor 3A Target Info Inhibitor [530012]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [530012]
KEGG Pathway Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP04375:5HT3 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channelsR-HSA-975298:Ligand-gated ion channel transportR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium ChannelsWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP706:SIDS Susceptibility Pathways
Iron uptake and transportWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 530012Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. Epub 2009 Feb 20.Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1.
Ref 530012Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. Epub 2009 Feb 20.Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1.

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