Drug Information

Drug General Information
Drug ID
D01GBY
Former ID
DAP000331
Drug Name
Desloratadine
Synonyms
Aerius; Allex; Azomyr; Claramax; Clarinex; Denosin; Desalex; Descarboethoxyloratadine; Descarboethoxyoratidine; Desloratidine; Neoclarityn; Opulis; Clarinex RediTabs; Desloratadine [USAN]; Essex brand of desloratadine; Schering brand of desloratadine; Sch 34117; Aerius (TN); Claramax (TN); Clarinex (TN); NeoClarityn (TN); Sch-34117; Schering-Plough brand of desloratadine; Desloratadine (USAN/INN); 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine; 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Approved [536542], [542165]
Therapeutic Class
Antiallergic Agents
Company
Schering-Plough
Structure
Download
2D MOL

3D MOL
Formula
C19H19ClN2
InChI
InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
InChIKey
JAUOIFJMECXRGI-UHFFFAOYSA-N
CAS Number
CAS 100643-71-8
PubChem Compound ID
124087
PubChem Substance ID
515991, 4480883, 10240975, 11528904, 12013632, 14742700, 14874264, 17397787, 25623633, 26719697, 26754458, 29215232, 29215233, 29304216, 46386563, 46507996, 49830094, 50086379, 53790902, 57340751, 75986670, 85209723, 85483828, 87561219, 92307949, 92308612, 92309042, 92712182, 93619677, 103341726, 103966640, 104420034, 104829344, 117782347, 124659138, 125325449, 125336452, 126584136, 126630167, 126656876, 126670272, 126728408, 128248166, 134337643, 134358654, 135078453, 135916143, 137001891, 142370109, 144076154
SuperDrug ATC ID
R06AX27
SuperDrug CAS ID
cas=100643718
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [537072], [537098]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536542Desloratadine treatment for intermittent and persistent allergic rhinitis: a review. Clin Ther. 2007 Sep;29(9):1795-802.
Ref 542165(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7157).
Ref 537072Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8.
Ref 537098Examining the tolerability of the non-sedating antihistamine desloratadine: a prescription-event monitoring study in England. Drug Saf. 2009;32(2):169-79. doi: 10.2165/00002018-200932020-00009.

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