Drug Information

Drug General Information
Drug ID
D01GZO
Former ID
DNC000077
Drug Name
5-amino orotate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535811]
Formula
C27H24N4O6
Canonical SMILES
CC1=NC(=O)C2=C(N1)C=CC3=C2C=C(C=C3)CNC4=CC5=C(C=C4)C(=O<br />)N(C5)C(CCC(=O)O)C(=O)O
InChI
1S/C27H24N4O6/c1-14-29-21-7-4-16-3-2-15(10-20(16)24(21)25(34)30-14)12-28-18-5-6-19-17(11-18)13-31(26(19)35)22(27(36)37)8-9-23(32)33/h2-7,10-11,22,28H,8-9,12-13H2,1H3,(H,32,33)(H,36,37)(H,29,30,34)/t22-/m0/s1
InChIKey
BRVFNEZMTRVUGW-QFIPXVFZSA-N
CAS Number
CAS 139987-54-5
PubChem Compound ID
60863
PubChem Substance ID
13548, 832470, 838745, 7887398, 7890949, 14810918, 14810919, 26711308, 26711508, 26711588, 38671766, 43118199, 46391849, 50064398, 57314159, 78210172, 85861037, 103424640, 103972850, 104321837, 117547675, 127559131, 134339613, 134340072, 135018138, 139226731, 139384957, 172918742, 179149901, 184527075, 198949478, 223779056, 227838849, 231822331, 252151330, 252811247
Target and Pathway
Target(s) Dihydroorotase Target Info Inhibitor [535811]
References
Ref 535811Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.
Ref 535811Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.

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