Drug Information

Drug General Information
Drug ID
D01HRV
Former ID
DIB020175
Drug Name
L-772,405
Synonyms
L-772405; L 772405
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538977]
Structure
Download
2D MOL
Formula
C26H31FN6O
InChI
InChI=1S/C26H31FN6O/c27-21-5-3-19(4-6-21)26(16-34)31-22-9-12-32(13-10-22)11-1-2-20-15-28-25-8-7-23(14-24(20)25)33-17-29-30-18-33/h3-8,14-15,17-18,22,26,28,31,34H,1-2,9-13,16H2/t26-/m0/s1
InChIKey
HNKDAQNYMJNLCC-SANMLTNESA-N
PubChem Compound ID
9847194
PubChem Substance ID
15429685, 24144072, 44945262, 76579725, 103298971, 103956192, 135650493, 230277793
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [525646]
5-hydroxytryptamine 1D receptor Target Info Antagonist [525646]
5-hydroxytryptamine 1B receptor Target Info Agonist [525646]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 538977(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 16).
Ref 5256463-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists. J Med Chem. 1999 Dec 2;42(24):4981-5001.

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