Drug Information

Drug General Information
Drug ID
D01JFT
Former ID
DAP000593
Drug Name
Dipivefrin
Synonyms
AKPro; Dipivefrina; Dipivefrine; Dipivefrinum; Propine; Dipivalyl epinephrine; Dipivefrin HCL; Dipivefrin [USAN]; K 30081; Dipivefrin (USAN); Dipivefrina [INN-Spanish]; Dipivefrine (INN); Dipivefrinum [INN-Latin]; Ophtho-Dipivefrin; Propine C Cap B.I.D.; [2-(2,2-dimethylpropanoyloxy)-4-[1-hydroxy-2-(methylamino)ethyl]phenyl] 2,2-dimethylpropanoate; (+-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol 3,4-dipivalate; (+-)-4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate; (-)-2,2-Dimethylpropansaeure-4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylenester; (-)-4-(1-Hydroxy-2-methylaminoethyl)-o-phenylendipivalat; (RS)-4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylen dipivalat; 1-(3',4'-dipivaloyloxyphenyl)-2-methylamino-1-ethanol; 2,2-Dimethylpropanoic acid 4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene ester; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylen dipivalat; 4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate; 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diyl bis(2,2-dimethylpropanoate)
Drug Type
Small molecular drug
Indication Chronic open-angle glaucoma [ICD10:H40] Approved [551871]
Therapeutic Class
Ophthalmologicals
Company
Allergan Pharmaceutical
Structure
Download
2D MOL

3D MOL
Formula
C19H29NO5
InChI
InChI=1S/C19H29NO5/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6/h8-10,13,20-21H,11H2,1-7H3
InChIKey
OCUJLLGVOUDECM-UHFFFAOYSA-N
CAS Number
CAS 52365-63-6
PubChem Compound ID
3105
PubChem Substance ID
9177, 5046070, 7849408, 7849627, 7979105, 8151976, 11466660, 11467780, 11486579, 14900877, 29222248, 46504716, 47730764, 47805070, 47953978, 48253458, 49699363, 50022390, 50124214, 57321612, 76534349, 85209619, 85787969, 99319096, 104302537, 108209497, 124974073, 126686842, 128790429, 134223686, 134337884, 135001947, 137125825, 142059953, 143311428, 160963795, 178103741, 179150547, 184547693, 221672763, 223672453, 226412985, 241092031, 250133605, 251912307, 251916618, 252348563
SuperDrug ATC ID
S01EA02
SuperDrug CAS ID
cas=052365636
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Antagonist [537986]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537986Contractile response of the isolated trabecular meshwork and ciliary muscle to cholinergic and adrenergic agents. Ger J Ophthalmol. 1996 May;5(3):146-53.

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