Drug Information

Drug General Information
Drug ID
D01KAX
Former ID
DNC006056
Drug Name
1-((S)-2-aminopropyl)-1H-indazol-6-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527952]
Structure
Download
2D MOL

3D MOL
Formula
C10H13N3O
Canonical SMILES
CC(CN1C2=CC(=O)C=CC2=CN1)N
InChI
1S/C10H13N3O/c1-7(11)6-13-10-4-9(14)3-2-8(10)5-12-13/h2-5,7,12H,6,11H2,1H3/t7-/m0/s1
InChIKey
CBKJGMYMAYOBDV-ZETCQYMHSA-N
PubChem Compound ID
9834183
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Inhibitor [527952]
Alpha-2C adrenergic receptor Target Info Inhibitor [527952]
5-hydroxytryptamine 2B receptor Target Info Inhibitor [527952]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [527952]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [527952]
5-hydroxytryptamine 2C receptor Target Info Inhibitor [527952]
Alpha-2A adrenergic receptor Target Info Inhibitor [527952]
5-hydroxytryptamine 4 receptor Target Info Inhibitor [527952]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
Serotonergic synapsehsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channelshsa04022:cGMP-PKG signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (s) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
References
Ref 527952J Med Chem. 2006 Jan 12;49(1):318-28.1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Ref 527952J Med Chem. 2006 Jan 12;49(1):318-28.1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.

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